Boswellic acids extract powder
Boswellic acids of frankincense resin part have increasing medical significance in fields of arthritis and joints health, inflammatory bowel disease (Crohn's disease and Ulcerative colitis), asthma, and post-traumatic conditions.

Ayub Laboratories developed unique boswellic acids extraction protocol where no contamination of any kind is allowed with any chemical and hence produced an absolute natural, organic, chemicals free boswellic acids extract.

Boswellic acids influence mast cell stabilization, inhibition of 5-Lipoxygenase (with subsequent decreased production of leukotrienes), inhibition of oxygen radicals and proteases (eg. elastase), reduced primary antibody titers and lymphocyte proliferation (at high doses), increase phagocytosis of macrophages, down regulation of TNF-alpha and decrease of IL-1, IL-2, IL-4, IL-6 and IFN-gamma, which are proinflammatory cytokines, and inhibition of prostaglandin synthesis.

Boswellic acids studies showed autoimmune process suppression that affect the pancreas , that causes asthma, Inflammatory Bowel Disease: Ulcerative Colitis , Crohn’s disease,
rheumatoid arthritis, and peritumoral brains edemas.
Studies of Boswellic acids on rheumatoid arthritis, osteoarthritis, chronic colitis, ulcerative colitis, collagenous colitis, Crohn's disease and bronchial asthma showed at least an improvement of symptoms in about 60-70 % of the cases.
Topical application of Boswellic acids showed improvement in 50-70% of erythematous eczema and psoriasis cases.
Boswellic acids reduced clinical symptoms of experimental autoimmune encephalomyelitis, and showed positive influence over pathogenesis of multiple autoimmune diseases like Th17 differentiation involved in the pathogenesis of several autoimmune diseases including multiple sclerosis, and antimicrobial peptide LL-37 that has immune system-modulating properties and roles in autoimmune disease development. 

That variation is explained by different concentration of amyrins (the biosynthesis precursors to boswellic acids that undergoes later consecutive oxidation and acetylation to different boswellic acids types) among different boswellia species. α-amyrin (precursor of β-boswellic acids) and β-amyrin (precursor of α-boswellic acids).

General Dosing Guidelines

• 300-500 mg orally two to three times daily, higher in inflammatory bowel disease (IBD).

Osteoarthritis

• Extract: 333 mg three times daily orally.

Rheumatoid Arthritis

• Extract: 3600 mg/day.

Ulcerative Colitis

• Gum Resin preparation: 350 mg three times daily orally.

Bronchial Asthma

• 300 mg three times daily orally.

Nigella sativa Thymoquinone
Thymoquinone, a trace component in Nigella sativa seeds, has a unique immunomodulatory effect through multiple pathways with beneficial potential against autoimmune pathologies. Its extraordinary effect overwhelm its extraction challenge.
Thymoquinone showed pathogenesis suppression against experimental autoimmune encephalomyelitis in the rat model of multiple sclerosis,(1) (2) (3) (4). Its topical application showed clinical improvement vitiligo that is an autoimmune skin disease.

Thymoquinone has anti-inflammatory preventing the biosynthesis of inflammatory mediators such as 5-Lipoxygenase, Cyclooxygenase , Prostaglandin D2 and Leukotrienes. Thymoquinone also reduce Lipopolysaccharides-induced pro-inflammatory cytokines such as interleukins and Tumor necrosis factor (TNF-α).

Thymoquinone easily crosses the blood-brain barrier due to its small size and lipophilicity (lipid solubility). Thymoquinone is a known inhibitor of neuroinflammation. Inhibition of neuroinflammation by thymoquinone involves activation of AMPK and SIRT1.

Grounded Nigella sativa seeds (with its low thymoquinone concentration) at a dose of 2 grams per day, used for 20 cases of Hashimoto’s thyroiditis (an autoimmune disorder and the most common cause of hypothyroidism) over 56 days (8 weeks) was able to reduce anti-thyroid peroxidase (anti-TPO) antibodies down to 50%, with improvement of thyroid functions.

Significant epidermal differentiation in psoriasis was produced by the ethanolic extract of Nigella sativa, 71.36 ± 2.64%. In the negative control the epidermal differentiation was 17.30 ± 4.09% and in the positive control (tazarotene 0.1%) was 90.03 ± 2.00%. The antiproliferant activity of the ethanolic extract of Nigella sativa was good, IC50 value of 23.9 μg/ml, as compared to that of the positive control, asiaticoside, which showed potent activity with IC50 value of 20.13 μg/ml.In conclusion, Nigella sativa oil had better effect as antiproliferative activity than the compared treatment. It is concluded based on many researches that Nigella sativa antipsoriatic effect with the best effect obtained with the combination of ointment and the oral dosage form.

After six months, a mean score of VASI (vitiligo area scoring index) decreased from 4.98 to 3.75 in patients treated with topical Nigella sativa fixed oil.